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| 336 BC |
| | | The League of Corinth elects Alexander to take his father's place as leader of the campaign against Persia | |
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| 335 BC |
| | | Before departing for the east, Alexander destroys Thebes and enslaves the Thebans for rebelling against the League of Corinth | |
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| 334 BC |
| | | The 21-year-old Alexander the Great marches east with some 5000 cavalry and 30,000 footsoldiers | |
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| 334 BC |
| | | Indulging in a moment of romantic tourism, Alexander visits Troy at the start of his Persian campaign | |
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| 334 BC |
| | | Alexander, recreating a classic Greek ceremony, runs naked in Troy to the supposed tomb of Achilles to place a garland | |
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| 334 BC |
| | | Alexander is presented in Troy with a shield, said to have been dedicated by Athena to the Trojans, which will always accompany him into battle | |
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| 334 BC |
| | | At the river Granicus, not far from Troy, Alexander defeats a Persian army employing many Greek mercenaries | |
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| 333 BC |
| | | At Issus, close to the Turkish border with Syria, Alexander defeats the Persian emperor Darius III, captures his family and treats them with courtesy | |
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| 333 BC |
| | | At Gordium, in central Turkey, Alexander is credited with cutting the mythical Gordian Knot (identifying him as the ruler of Asia) | |
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| 332 BC |
| | | Alexander moves south through Syria and Palestine, excluding the Persian fleet from their familiar harbours | |
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